Customer Publication

Momordicoside G Regulates Macrophage Phenotypes to Stimulate Efficient Repair of Lung Injury and Prevent Urethane-Induced Lung Carcinoma Lesions

Authors: Z. Du et al.

Journal: Frontiers in Pharmocology (2019)

Institution: Henan University

Research Areas: Tissue regeneration

Cell Lines: RAW 264.7 (Murine cell line, macrophages from blood)

Summary: In this study, Z. Du et al. have explored the contributions of macrophages to the effects of momordicoside G on lung injury and carcinoma lesions. Momordicoside G is a bioactive component from Momordica charantia, which is used in various traditional Chinese, Southeast Asian, and South African remedies. Authors have showed that momordicoside G can selectively suppress M1 type macrophages to maintain M2 type macrophages for lung injury repair and prevent inflammation-related lung carcinogenesis and in combination they promote lung injury repair. HoloMonitor M4 was employed to evaluate momordicoside G effects (at 40 µM concentration) on macrophage morphology in vitro. The results showed that M1 type macrophage volume and area decrease and cells underwent apoptosis, while M2 type macrophages were unaffected.

Keywords: HoloMonitor M4, cell morphology, momordicoside G, macrophage phenotypes, lung injury, carcinoma lesions, injury repair

Read the article …

Phase Holographic Imaging PHI AB
Skiffervägen 48
224 78 Lund
Sweden
+46 46 38 60 80
info@phiab.se

Phase Holographic Imaging PHI Inc.
265 Franklin Street Suite 1702
Boston, MA 02110
USA
+1 617-963-5150
info@phiab.com

Invoicing

VAT: SE556542781101
faktura@phiab.se

Securities Identification

ISIN: SE0005504636
LEI: 549300JZR79QYESM6296

HoloMonitor® is a registered trademark
Copyright © 2012-2021
Phase Holographic Imaging PHI AB

Phase Holographic Image logo in white

PHI Theme 3.12.2