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Momordicoside G Regulates Macrophage Phenotypes to Stimulate Efficient Repair of Lung Injury and Prevent Urethane-Induced Lung Carcinoma Lesions

Authors: Zhenhua Du, Shuhui Zhang, Yukun Lin, Lin Zhou, Yuehua Wang, Guixi Yan, Mengdi Zhang, Mengqi Wang, Jiahuan Li, Qiaozhen Tong, Yongjian Duan, Gangjun Du

Journal: Frontiers in Pharmocology (2019)

Institution: Henan University

Research Areas: Cancer research

Cell Lines: RAW 264, 7 (Murine cell line, macrophages from blood)

Summary: In this study, Z. Du et al. have explored the contributions of macrophages to the effects of momordicoside G on lung injury and carcinoma lesions. Momordicoside G is a bioactive component from Momordica charantia, which is used in various traditional Chinese, Southeast Asian, and South African remedies. Authors have showed that momordicoside G can selectively suppress M1 type macrophages to maintain M2 type macrophages for lung injury repair and prevent inflammation-related lung carcinogenesis and in combination they promote lung injury repair. HoloMonitor M4 was employed to evaluate momordicoside G effects (at 40 µM concentration) on macrophage morphology in vitro. The results showed that M1 type macrophage volume and area decrease and cells underwent apoptosis, while M2 type macrophages were unaffected.

Keywords: HoloMonitor M4, cell morphology, momordicoside G, macrophage phenotypes, lung injury, carcinoma lesions, injury repair, Tissue regeneration

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