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Monobutyl phthalate can induce autophagy and metabolic disorders by activating the ire1a-xbp1 pathway in zebrafish liver

Authors: Ying Zhang, Yaqi Jiao, Yue Tao, Zixu Li, Hui Yu, Siyue Han, Yang Yang

Journal: Journal of Hazardous Materials (2021)

Institution: Northeast Agricultural University, Harbin

Research Areas: Toxicology

Cell Lines: Zebra fish (AB strain) liver cells (Primary hepatocytes extracted from adult zebra fish (AB strain))

Summary: Monobutyl phthalate (MBP) and dibutyl phthalate (DBP) may have similar toxicity. Thus, in this study, Y. Zhang with colleagues assess the MBP effect on zebrafish. Authors revealed that MBP introduces acute toxicity to zebra liver, leading to disturbances in metabolism while triggering cell autophagy. HoloMonitor M4 was used to observe MBP effects on hepatocyte cell morphology, including cell area, thickness, irregularity, and roughness.

Keywords: HoloMonitor M4, cell morphology, ER stress, UPR pathway, Autophagy, Glucose metabolism, Lipid metabolism, Chemical toxicity

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