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Monobutyl phthalate (MBP) induces energy metabolism disturbances in the gills of adult zebrafish (Danio rerio)

Authors: Yue Tao, Yang Yang, Yaqi Jiao, Song Wu, Guangxue Zhu, Modupe Sarah Akindolie, Tong Zhu, Jianhua Qu, Lei Wang, Ying Zhang

Journal: Environmental Pollution (2020)

Institution: Northeast Agricultural University

Research Areas: Toxicology

Cell Lines: Zebra fish (Danio rerio) gill epithelial cells (Primary gill epithelial cells extracted from adult zebra fish (Danio rerio))

Summary: Monobutyl phthalate (MBP) is a primary metabolite of an environmental endocrine disruptor dibutyl phthalate, which is a threat to ecosystems. In this study, Y. Tao with coworkers has studies MBP effects on energy metabolism in the zebrafish respiratory system (gills). Authors show that MBP is acutely toxic by destroying mitochondria structure and function, disrupting ATP synthesis and ion transport, and leads to cell death. HoloMonitor M4 was used to study gill epithelial cell morphology changes exposure to various concentrations of MBP.

Keywords: HoloMonitor M4, Cell morphology, Monobutyl phthalate, Zebrafish, Gills damage, Energy metabolism, Chemical toxicity

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