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Multiscale Materials Engineering via Self-Assembly of Pentapeptide Derivatives from SARS CoV E Protein
Journal: Small (2024)
Research Areas: Materials Science
Cell Lines: SW-620 (human colon adenocarcinoma)
Summary: Short peptide-based hydrogels hold significant potential for biomedical applications, including targeted drug delivery and cell culture scaffolds. This study examines three pentapeptide sequences derived from the C-terminal region of the SARS-CoV envelope (E) protein and their impact on hydrogel gelation. Using the HoloMonitor M4, the effects of these peptides on colon adenocarcinoma SW-620 cells were assessed by monitoring cell count, confluence, and volume. The authors highlight live-cell imaging with digital holography as a superior method compared to traditional static imaging and endpoint assays like MTT.