N-terminal acetylation of actin by NAA80 is essential for structural integrity of the golgi apparatus
Journal: Experimental Cell Research (2020)
Institution: University of Bergen
Research Areas: Cell Research
Cell Lines: HAP1 (Near-haploid human cell)
Summary: Actin is a cell skeleton and is responsible for not only cell movements, but also for molecule transport and organization of other organelles, such as Golgi apparatus. In this study, T. B. Beigl with colleagues has evaluated how actin structure, N-terminus acetylation, and actin amounts affect Golgi apparatus structure and dynamics. Authors have used HoloMonitor M4 to quantitatively assess cell morphology parameters - area, volume, and irregularity - change after N-terminus acetylation protein knockout.