Customer Publication

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

Authors: Junyi Ju, Aiping Chen, Yexuan Deng, Ming Liu, Ying Wang, Yadong Wang, Min Nie, Chao Wang, Hong Ding, Bing Yao, Tao Gui, Xinyu Li, Zhen Xu, Chi Ma, Yong Song, Marc Kvansakul, Ke Zen, Chen-Yu Zhang, Cheng Luo, Ming Fang, David C. S. Huang, C. David Allis, Renxiang Tan, Changjiang Kathy Zeng, Jiwu Wei, Quan Zhao

Journal: Nature Communications (2017)

Institution: Nanjing University

Research Areas: Cancer research

Cell Lines: human lung cancer cells (Two independent, stable NatD knockdown human lung cancer H1299 cell lines developted by the authors)

Summary: The authors report that NatD (N-α-acetyltransferase D) promotes the migratory and invasive capabilities of lung cancer cells in vitro and in vivo. On the other hand, depletion of NatD suppresses the epithelial-to-mesenchymal transition (EMT) of lung cancer cells. These findings indicate that NatD is a crucial epigenetic modulator of cell invasion during lung cancer progression.

Keywords: HoloMonitor M4, Cell viability, Cell migration, Lung cancer

Read the article …