Nuclear respiratory factor 1 acting as an oncoprotein drives estrogen-induced breast carcinogenesis

Authors: J. Das et al.

Journal: Cells (2018)

Institution: Florida International University

Research Areas: Cancer research

Cell Lines: MCF-10A, MCF-7, and MDA-MB231 (MCF-10A human breast epithelia cells, MCF-7 breast cancer cell line, MDA-MB231 human breast adenocarcinoma)

Summary: The findings of this study provide a new understanding of the mechanism of estrogen-induced malignant transformation of MCF10A cells (human breast epithelial cells) by NRF1 (nuclear respiratory factor 1). HoloMonitor was used for imaging of the formation of tumor spheroids used in the study, and for assessment of migration. The authors hope that their findings may open new avenues for therapies against breast cancer.

Keywords: HoloMonitor M4, Spheroids formation, Cell migration, estrogen, Breast cancer stem cell, NRF1, Oncoprotein, Re-programming

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