Nuclear respiratory factor 1 acting as an oncoprotein drives estrogen-induced breast carcinogenesis

J. Das et al.

Cells (2018)

Institution: Florida International University, USA

Cell Line: MCF-10A, MCF-7, and MDA-MB231 (MCF-10A human breast epithelia cells, MCF-7 breast cancer cell line, MDA-MB231 human breast adenocarcinoma)

Research Area: Cancer research

Tags: HoloMonitor M4, Spheroids formation, Cell migration, estrogen, Breast cancer stem cell, NRF1, Oncoprotein, Re-programming

Conclusions: The findings of this study provide a new understanding of the mechanism of estrogen-induced malignant transformation of MCF10A cells (human breast epithelial cells) by NRF1 (nuclear respiratory factor 1). HoloMonitor was used for imaging of the formation of tumor spheroids used in the study, and for assessment of migration. The authors hope that their findings may open new avenues for therapies against breast cancer.

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