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Ouabain suppresses the growth and migration abilities of glioma U‑87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF‑1α

Authors: Xiao‑Sa Yang, Zhong‑Wei Xu, Tai‑Long Yi, Rui‑Cheng Xu, Jie Li, Wen‑Bin Zhang, Sai Zhang, Hong‑Tao Sun, Ze‑Qi Yu, Hao‑Xiang Xu, Yue Tu, Shi‑Xiang Cheng

Journal: Molecular Medicine Reports (2017)

Institution: Tianjin Key Laboratory of Neurotrauma Repair

Research Areas: Cancer Research

Cell Lines: U87MG cells (Human glioblastoma)

Summary: The present study revealed that ouabain intervention inhibited U‑87MG cell viability and cell motility in a dose‑dependent manner, suggesting that ouabain promoted the apoptosis of U87‑MG cells. HoloMonitor was used to analyze cell motility, cell count and to study the 3D cell structure.

Keywords: HoloMonitor M4, Cell motility, Ouabain, Glioblastoma, Akt/mammalian target of rapamycin signaling pathway, Hypoxia-inducible factor-1α

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