Ouabain suppresses the growth and migration abilities of glioma U‑87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF‑1α

X. Yang et al.

Molecular Medicine Reports (2017)

Institution: Logistics University of PAP, China

Cell Line: U87MG cells (Human glioblastoma)

Research Area: Cancer Research

Tags: HoloMonitor M4, Cell motility, Ouabain, Glioblastoma, Akt/mammalian target of rapamycin signaling pathway, Hypoxia-inducible factor-1α

Conclusions: The present study revealed that ouabain intervention inhibited U‑87MG cell viability and cell motility in a dose‑dependent manner, suggesting that ouabain promoted the apoptosis of U87‑MG cells. HoloMonitor was used to analyze cell motility, cell count and to study the 3D cell structure.

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