Poloxamer Bioadhesive Hydrogel for Buccal Drug Delivery: Cytotoxicity and Trans-epithelial Permeability Evaluations Using Tr146 Human Buccal Epithelial Cell Line

N. Zeng et al.

International journal of pharmaceutics (2015)

Institution: Paris Descartes University, France

Cell Line: Tr146 (Human buccal epithelial cell line)

Research Area: Drug development

Tags: Holomonitor M3, Pluronic, Xanthan gum, Buccal tolerance, Necrosis, Apoptosis, Digital holographic microscopy

Conclusions: The assessment of cell viability (MTT, Alamar Blue), membrane integrity (Neutral Red), and apoptosis assay (Hoechst 33342), were performed and associated with holomonitor M3 analysis.

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