Propofol prevents oxidative stress and apoptosis by regulating iron homeostasis and targeting JAK/STAT3 signaling in SH-SY5Y cells
Brain Research Bulletin (2019)
Institution: Fourth Hospital of Hebei Medical University, China
Cell Line: SH-SY5Y (Human neuroblastoma cell line)
Research Area: Neurodegenerative disorders
Conclusions: Y. Zhang with colleagues have demonstrated a new antioxidation mechanism of propofol, an intravenous anesthetic. Propofol could protect against nerve cell injury, induced by overload of iron through regulating iron metabolism and inhibiting stress and inflammation reaction pathways. Authors have used HoloMonitor M4 to confirm that propofol suppressed cell apoptosis by evaluating cell count.