Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer

M. Sarwara et al.

Urologic Oncology (2014)

Institution: Lund university, Sweden

Cell Line: LNCaP, PC3 (Human prostate cancer cell lines)

Research Area: Cancer research

Tags: HoloMonitor M3, cell morphology, rolipram, ForskolinAR, cAMP/PKA pathways, CaP metastasis

Conclusions: The study aimed to explore a suggested signaling pathway in the progression of prostate cancer. The study revealed a novel mechanism to precisely define the functional and clinical interrelationship between the cAMP/PKA pathway and AR signaling in developing androgen-independent growth of CaPs and metastasis progression. HoloMonitor M3 was used for imaging of cells and analysis of morphological parameters.

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