Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer
Journal: Urologic Oncology (2014)
Institution: Lund university
Research Areas: Cancer research
Cell Lines: LNCaP, PC3 (Human prostate cancer cell lines)
Summary: The study aimed to explore a suggested signaling pathway in the progression of prostate cancer. The study revealed a novel mechanism to precisely define the functional and clinical interrelationship between the cAMP/PKA pathway and AR signaling in developing androgen-independent growth of CaPs and metastasis progression. HoloMonitor M3 was used for imaging of cells and analysis of morphological parameters.