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Reduction of the Putative CD44+CD24 Breast Cancer Stem Cell Population by Targeting the Polyamine Metabolic Pathway With Pg11047

Authors: Helenaa Cirenajwis, Sandraa Smiljanic, Gabriellab Honeth, Ceciliab Hegardt, Laurence J.c Marton, Stina M.a Oredsson

Journal: Anticancer Drugs (2010)

Institution: Lund University

Research Areas: Drug research

Cell Lines: JIMT-1 (Human breast cancer)

Summary: Cirenajwis and colleagues used the label-free live cell imaging capabilities of the HoloMonitor to study the movement of JIMT-1 breast cancer cells. They showed that treatment with the ornithine analogue difluoromethylor-nithine (DFMO) increased cell motility, while treatment with the polyamine analogue PG-11047 decreased cell motility.

Keywords: HoloMonitor M2, cell motility, breast cancer stem cells, mesenchymal-to-epithelial transition, [1N, 12N]bis(ethyl)-cis-6, 7-dehydrospermine, polyamine analogue, drug development

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