Reversal of Chemoresistance in Ovarian Cancer by Co-delivery of a p-glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform

Y. Zhang et al.

Molecular Cancer Therapeutics (2016)

Institution: University of Chicago, Cancer

Cell Line: SKOV 3 TR cells (Ovarian cancer cell line)

Research Area: Cancer research

Tags: HoloMonitor M4, Cell cycle arrest, Apoptosis, Ovarian cancer

Conclusions: The authors created a nanoparticle formulation against chemotherapy resistant ovarian cancer, loaded with the commonly used cancer drug paclitaxel together with a drug that breaks down the resistance mechanism of cancer cells. Using HoloMonitor, the scientists were able to show that paclitaxel-resistant ovarian cancer cells stopped multiplying when treated with the nanoparticles.

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