Customer Publication
Ropivacaine and lidocaine at clinically relevant concentrations suppress proliferation and migration of ovarian cancer cells and induce morphological alterations
Journal: Advances in Medical Sciences (2025)
Research Areas: Cancer Research
Cell Lines: SKOV-3, SW-626 and CA-OV-3 (ovarian cancer cell lines)
Summary: The authors set out to test whether two commonly used local anaesthetics — Ropivacaine and Lidocaine — when used at concentrations close to those seen clinically, can affect the behaviour of ovarian cancer cells. Specifically, they wanted to know if these drugs might suppress cancer-cell proliferation (growth) and migration (movement) and possibly induce cell death (apoptosis) in ovarian cancer cell lines. The study found that both ropivacaine and lidocaine, at clinically relevant concentrations, reduced the proliferation of ovarian cancer cells. They also observed reduced migration of these cells in treated samples compared to controls. In addition, the drugs induced apoptosis in the cancer cells. The authors conclude that the findings raise the possibility that the local anaesthetics may have a therapeutic adjunct effect in the setting of ovarian cancer. HoloMonitor was used to study the morphology (optical thickness) differences between treated and control.