Customer Publication

Sensitizing cholangiocarcinoma to chemotherapy by inhibition of the drug-export pump MRP3

Authors: Maitane Asensio et al.

Journal: Biomedicine & Pharmacotherapy (2024)

Research Areas: Cancer research

Cell Lines: primary human hepatobiliary cancer, EGI-1, TFP-1, HEK293T, AGS (EGI-1 (ACC 385) and TFK-1 (ACC 344) were cells derived from eCCA cases, HEK293T is a human embryonic kidney cell line, the AGS cell line is derived from human gastric adenocarcinoma)

Summary: The authours have evaluted cell responses to a combined treatment of an inihibitor of the ABC-protein pump and a chemotherapeutic drug. Inhibiting the drug export through the pump increased intracellular concentrations of the chemptheraputic drugs as well as the effect of the drugs on the cells. HoloMonitor M4 was used to monitor cell proliferation as a measure of drug impact. Control and inhibitor-only groups showed similar proliferation rates. However, etoposide significantly reduced the growth rate, which was markedly enhanced by co-treatment with an inihibitor of the ABC-protein pump.

Keywords: ABC transporters, biliary tract cancer, chemosensitization, tyrosine kinase inhibitors, natural products

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