Single cell analysis of proliferation and movement of cancer and normal-like cells on nanowire array substrates
J. Mater. Chem. B (2018)
Institution: Lund University, Sweden
Cell Line: MCF10A, JIMT-1 (MCF-10 A: human breast epithelia cells, JIMT-1 human breast cancer cells)
Research Area: Nanomaterials and cell interactions
Conclusions: The article presents a single cell analysis of cell cycle and cell movement parameters of cells seeded on nanowires using HoloMonitor M4 for time-lapse imaging. Nanowires are presently investigated in the context of various biological and medical applications. In general, these studies are population-based, which results in sub-populations being overlooked. Altogether, this study highlight the importance of performing single cell analysis to increase our understanding of the versatility of cell behavior on different substrates.