Small leucine zipper protein promotes the metastasis of castration-resistant prostate cancer through transcriptional regulation of matrix metalloproteinase-13
Journal: Carcinogenesis (2021)
Institution: Korea University
Research Areas: Cancer research
Cell Lines: LNCaP, 22Rv1, PC3, DU145, and PWR-1E (Human prostate cancer cell, human prostate carcinoma epithelial cell line, human prostatic epithelial cells)
Summary: Matrix metalloproteinases (MMPs) function as central modulators of tissue remodeling. Abnormal expression and altered activity of MMPs result in excessive extracellular matrix degradation and increased tumor metastasis in various cancers. Small leucine zipper protein (sLZIP) functions as a transcriptional regulator. However, its role in MMP expression and castration-resistant prostate cancer (CRPC) metastasis remains unclear. In this study, the authors investigated the role of sLZIP in MMP-13 expression and its involvement in CRPC metastasis. Results suggested that sLZIP plays an important role in MMP-13 induction and CRPC metastasis. Therefore, sLZIP inhibition could be a novel therapeutic strategy for metastatic GR-enriched CRPC. HoloMonitor M4 was used for cell motility and single cell tracking study.