Smart drug combinations for cervical cancer: dual targeting of Bcl-2 family of proteins and aurora kinases

Authors: J. Yumol et al.

Journal: Am J Cancer Res (2020)

Institution: Griffith University

Research Areas: Cancer research

Cell Lines: HeLa (Human cervical cancer cell line)

Summary: Current available cervical cancer treatments are not always sufficient and result in cancer recurrence. In this publication, ÇJ. Yumol and colleagues have studied how the treatment efficacy can be enhanced by combining Alisertib drug with Bcl-2 family anti-apoptotic protein inhibitors. Authors have shown that having this type of combination accelerates cell apoptosis during the mitotic delay. Here, HoloMonitor M4 was used to study cell cycle, e.g. mitosis time and the number of cell divisions, after drug treatments.

Keywords: HoloMonitor M4, cell morphology, HPV, aurora kinase, cervical cancer, alisertib

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