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Snail Overexpression Alters the microRNA Content of Extracellular Vesicles Released from HT29 Colorectal Cancer Cells and Activates Pro-Inflammatory State In Vivo

Authors: Izabela Papiewska-Pająk, Patrycja Przygodzka, Damian Krzyżanowski, Kamila Soboska, Izabela Szulc-Kiełbik, Olga Stasikowska-Kanicka, Joanna Boncela, Małgorzata Wągrowska-Danilewicz, M. Anna Kowalska

Journal: Cancers (2021)

Institution: Polish Academy of Sciences

Research Areas: Cancer research

Cell Lines: HT-29 (Human colon cancer cell line)

Summary: Extracellular vesicles (EV) released by cancer cells have a role as intercellular communicators in the cancer metastasis process. I. Papiewska-Pajak with colleagues have studied how EV released from various types of HT-29 cells affect cancer progression. Authors have shown that HT-29 cells affected by Snail transcription factors release EVs with modified microRNA cargo and lead to more invasive cell phenotype. HoloMonitor M4 was used to study cell motility speed and migration after EV treatment.

Keywords: HoloMonitor M4, cell motility, snail transcription factor, extracellular vesicles, colon cancer, pre-metastatic niche

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