Snail Overexpression Alters the microRNA Content of Extracellular Vesicles Released from HT29 Colorectal Cancer Cells and Activates Pro-Inflammatory State In Vivo
Institution: Polish Academy of Sciences, Poland
Cell Line: HT-29 (Human colon cancer cell line)
Research Area: Cancer research
Conclusions: Extracellular vesicles (EV) released by cancer cells have a role as intercellular communicators in the cancer metastasis process. I. Papiewska-Pajak with colleagues have studied how EV released from various types of HT-29 cells affect cancer progression. Authors have shown that HT-29 cells affected by Snail transcription factors release EVs with modified microRNA cargo and lead to more invasive cell phenotype. HoloMonitor M4 was used to study cell motility speed and migration after EV treatment.