Spinosyn A exerts anti-tumorigenic effects on progesterone-sensitive ERα-positive breast cancer cells by modulating multiple signaling pathways
Journal: Biomedicine & Pharmacotherapy (2024)
Institution: University of Michigan-Dearborn
Research Areas: Cancer Research
Cell Lines: T47-D (human breast cancer cell line)
Summary: The paper describes the effects of Spinosyn A, a natural insecticide, on breast cancer cells. The study found that Spinosyn A has anti-tumorigenic effects on progesterone-sensitive ERα-positive breast cancer cells by modulating multiple signaling pathways. The authors of the study used various techniques to investigate the effects of Spinosyn A on breast cancer cells, including cell viability assays, western blotting, and qPCR. They found that Spinosyn A inhibits the growth of breast cancer cells by inducing apoptosis and cell cycle arrest. Additionally, Spinosyn A was found to modulate multiple signaling pathways, including the PI3K/Akt/mTOR pathway, the MAPK/ERK pathway, and the JAK/STAT pathway. The authors used HoloMonitor M4 to monitor the effects of Spinosyn A on breast cancer cells with cell morphology and proliferation, providing valuable insights into the mechanisms underlying the anti-tumorigenic effects of Spinosyn A.