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SUMOylation of PUM2 promotes the vasculogenic mimicry of glioma cells via regulating CEBPD

Authors: Di Wang, Xuelei Ruan, Xiaobai Liu, Yixue Xue, Lianqi Shao, Chunqing Yang, Lu Zhu, Yang Yang, Zhen Li, Bo Yu, Tianda Feng, Yunhui Liu

Journal: Clinical and Translational Medicine (2020)

Institution: Shengjing Hospital of China Medical University

Research Areas: Cancer research

Cell Lines: U251, U373 (U251 – human glioblastoma astrocytoma, U373 – human glioblastoma astrocytoma)

Summary: 40 % of primary intracranial tumors are glioma and is the most common primary tumor. Additionally, it is hard to treat as it is invasive and prone to recurrence. Thus in this paper, D. Wang with colleagues have studied what is the role of SUMOylation, expression, and interaction in vasculogenic mimicry, which is a blood supply channel in glioma. Authors have shown that UBE21/PUM2/CEBPD/DSG2 gene expression plays a crucial role in regulating glioma vasculogenic mimicry. In this study, HoloMonitor M4 was used to study glioma cell migration capacity after transfection.

Keywords: HoloMonitor M4, cell movements, CEBPD, PUM, SUMOylation, UBEI, vasculogenic mimicry

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