Supervised Classification of Etoposide-treated in Vitro Adherent Cells Based on Noninvasive Imaging Morphology

A. Mölder et al.

Journal of Medical Imaging (2017)

Institution: Malmö University, Sweden

Cell Line: DU-145 (Prostate cancer cells)

Research Area: Image-based analysis, cell classification

Tags: HoloMonitor M4, cell morphology, Image segmentation Image analysis In vitro testing, Digital holography Image classification, Microscopy, Biological research, Digital imaging, Holography, In vivo imaging

Conclusions: The morphological changes observed occur before and at lower concentrations than a reduction in cell metabolic activity or viability. Three classifiers are compared and we report a best case sensitivity of 88% and specificity of 94% for classification of cells as treated/untreated.

Read the article …