Synthesis, Characterization and in Vitro and in Vivo Photodynamic Activities of a Gallium(III) Tris(Ethoxycarbonyl)corrole
Journal: Dalton Transactions (2017)
Institution: South China University of Technology
Research Areas: Photo-cytotoxicity; photodynamic therapy (PDT)
Cell Lines: A549 (Human lung carcinoma cells)
Summary: After illumination and treatment with 1-Ga, A549 cells exhibited characteristics typical of apoptosis, spherical shape of the cells, chromatin condensation, and nuclear membrane irregularity. After incubation for 1 h, the authors found that the cells started to contract, the area decreased and the thickness increased.