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Targeted Delivery of Combination Therapeutics Using Monoclonal Antibody 2C5-Modified Immunoliposomes for Cancer Therapy
Journal: Pharmaceutical Research (2021)
Institution: Northeastern University
Research Areas: Drug research
Cell Lines: MDA-MD-231 (Human mammary carcinoma cell line)
Summary: Improving the various properties, such as biodistribution and solubility, are the main driving force for using nano-carries in drug deliveries. In this study, the authors have used monoclonal antibody modified immunoliposomes for targeted delivery of paclitaxel and salinomycin for cancer therapy. Researchers have shown that a combination of drugs increases therapeutical efficacy when delivered in immunoliposomes. HoloMonitor M4 was used to study cell killing, cell division and proliferation post-treatment.