Tau Phosphorylation and Amyloid-β Deposition in the Presence of Formaldehyde

J. Lu et al.

Formaldehyde and Cognition (2017)

Institution: University of Chinese Academy of Sciences, China

Research Area: Alzheimer’s disease

Tags: Formaldehyde, Methanol, Tau hyperphosphorylation, Neurofibrillary tangles, Tauopathy, Amyloid-β Senile plaque, Cognitive impairment, APOE4 Neurite, Neuronal processes, Cell death, Mouse model, Nonhuman primate, Dephosphorylation, Pathology

Conclusions: Mechanisms related to Alzheimer’s disease (AD). Formaldehyde is shown to be a strong trigger of Aβ deposition and Tau phosphorylation, so that the dysmetabolism of endogenous formaldehyde should occur in the early stage of AD as formaldehyde disturbs nervous system in different pathways and in diverse manners.

Read the article …