Tau Phosphorylation and Amyloid-β Deposition in the Presence of Formaldehyde

Authors: J. Lu et al.

Journal: Formaldehyde and Cognition (2017)

Institution: University of Chinese Academy of Sciences

Research Areas: Alzheimer’s disease

Summary: Mechanisms related to Alzheimer’s disease (AD). Formaldehyde is shown to be a strong trigger of Aβ deposition and Tau phosphorylation, so that the dysmetabolism of endogenous formaldehyde should occur in the early stage of AD as formaldehyde disturbs nervous system in different pathways and in diverse manners.

Keywords: Formaldehyde, Methanol, Tau hyperphosphorylation, Neurofibrillary tangles, Tauopathy, Amyloid-β Senile plaque, Cognitive impairment, APOE4 Neurite, Neuronal processes, Cell death, Mouse model, Nonhuman primate, Dephosphorylation, Pathology

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