The human papillomavirus confers radiosensitivity in oropharyngeal cancer cells by enhancing DNA double strand break
Journal: Oncotarget (2020)
Institution: The University of Sydney
Research Areas: Cancer research
Cell Lines: OPSCC (Oropharyngeal squamous cell carcinoma)
Summary: HoloMonitor M4The overall better prognosis seen in Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) may be related to the disease's response to radiation therapy. Radiation therapy plays an important role in the management of OPSCC, either as definitive therapy or as adjuvant therapy after surgery. In this study, M. Zhang and A. M. Hong have studied how HPV and its E6 oncoprotein affect cell morphology, radiosensitivity, and repair of radiation-induced DNA damage. Authors have shown that HPV-positive OPSCC was more radiosensitive and that E6 oncoprotein enhanced HPV-negative OPSSC cell radiosensitivity by impairing the DNA repair mechanism and enhancing apoptotic death. Authors have studied cellular response to radiation treatment with HoloMonitor M4 and observed cell migration and morphology changes.