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The impact of circulating preeclampsia-associated extracellular vesicles on the migratory activity and phenotype of THP-1 monocytic cells

Authors: Árpád Ferenc Kovács, Orsolya Láng, Lilla Turiák, András Ács, László Kőhidai, Nóra Fekete, Bálint Alasztics, Tamás Mészáros, Edit Irén Buzás, János Rigó, Jr., Éva Pállinger

Journal: Scientific Reports (2018)

Institution: Semmelweis University

Research Areas: Immunology

Cell Lines: THP-1 (Monocytes)

Summary: The study suggests that circulating extracellular vesicles (EVs) activate THP-1 monocytes, induce intra-monocytic TNF expression, as well as an altered chemotaxis and cell migration pattern. This is the first study to investigate in preeclampsia the effects of circulating EVs on monocyte chemotaxis, cell adhesion, and migration in vitro.The HoloMonitor M4 was used for cell tracking of adherent cells. In the present experiments, the chemokinetic effects were evaluated by measurement and calculation of migration and motility.

Keywords: HoloMonitor M4, Cell motility, Cell migration, Pathogenesis in preeclampsia

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