The long noncoding RNA TP73‐AS1 promotes tumorigenicity of medulloblastoma cells

Authors: M. Varon et al.

Journal: International Journal of Cancer (2019)

Institution: Department of Life Sciences Ben-Gurion University of the Negev Beer Sheva

Research Areas: Cancer research

Cell Lines: DAOY, UW 228.2 (DAOY - human primary medulloblastoma cell line UW228.2 -  pediatric primary brain tumor cell line)

Summary: M. Varon with co-authors focused their research on medulloblastoma - the most common malignant brain cancer in children. Authors have studied what functions a long noncoding RNA, specifically TP73-AS1, perform. In this study, results show that the high expression of TP73-AS1 can be associated with poor outcome in some patients. Furthermore, silencing on TP73-AS1 in tumor cells induce cell apoptosis and reduce cell proliferation and motility rates in vitro, and prolonged sur.vival of tumor bearing mice in vivo. Authors have employed HoloMonitor M4 to evaluate TP73-AS1 effect on cell motility and showed that it promotes migration of tumor cells, DAOY and UW288.2

Keywords: HoloMonitor M4, cell migration and motility, wound healing, gene regulation, sonic hedgehog, oncogene

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