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The osteogenic commitment of CD271+CD56+ bone marrow stromal cells (BMSCs) in osteoarthritic femoral head bone

Authors: Dragos C. Ilas, Thomas G. Baboolal, Sarah M. Churchman, William G. Jones, Peter V. Giannoudis, Hans-Jörg Bühring, Dennis McGonagle, Elena Jones

Journal: Scientific Reports (2020)

Institution: The University of Leeds

Research Areas: Stem cell research

Cell Lines: BMSC (Bone marrow stromal cells)

Summary: Progressive structural changes in cartilage and subchondral bone lead to osteoarthritis. In this study, D.C. Ilas with colleagues have sorted cells and used immunohistochemistry to phenotypically distinguish, osteogenically-committed bone marrow stromal cell (BMSC) subset in human osteoarthritic trabecular bone. Authors have shown that two genes, responsible for a nerve growth factor (CD271) and neural cell adhesion molecule (CD 56) expression, could be utilized as a future therapeutic target for osteoarthritis and other bone-associated pathologies. In this study, HoloMonitor M4 was used to study how BMSC cell motility is affected by cell morphology.

Keywords: HoloMonitor M4, Cell movements, stem cell therapy

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