The osteogenic commitment of CD271+CD56+ bone marrow stromal cells (BMSCs) in osteoarthritic femoral head bone
Scientific Reports (2020)
Institution: The University of Leeds, UK, Germany
Cell Line: BMSC (Bone marrow stromal cells)
Research Area: Stem cell therapy
Conclusions: Progressive structural changes in cartilage and subchondral bone lead to osteoarthritis. In this study, D.C. Ilas with colleagues have sorted cells and used immunohistochemistry to phenotypically distinguish, osteogenically-committed bone marrow stromal cell (BMSC) subset in human osteoarthritic trabecular bone. Authors have shown that two genes, responsible for a nerve growth factor (CD271) and neural cell adhesion molecule (CD 56) expression, could be utilized as a future therapeutic target for osteoarthritis and other bone-associated pathologies. In this study, HoloMonitor M4 was used to study how BMSC cell motility is affected by cell morphology.