The photocytotoxicity effect of cationic sulfonated corrole towards lung cancer cells: in vitro and in vivo study
Journal: Lasers in Medical Science (2019)
Institution: Guangdong Medical University, Zhanjiang
Research Areas: Cancer research
Cell Lines: A549 (Human adenocarcinoma lung cells)
Summary: Z. Zhang with co-authors have studied the effects of cationic sulfonated corrole after irradiation with light on lung cancer in vitro and in vivo. Authors showed that synthesized chemical has a potential to be employed as a potential photosensitizer as it can induce A549 cell apoptosis by increasing ROS levels and activating mitochondrial apoptosis pathway. In this study, HoloMonitor M3 was used to study A549 cell morphology changes in time for 24 hours after exposure to corrole and light irradiation and controls for 1 hour. Authors have shown a decrease in A549 cell volume after 1 hour of light illumination and corrole administration.