The Role of Pi3k/akt-related Pip5k1α and the Discovery of Its Selective Inhibitor for Treatment of Advanced Prostate Cancer
Journal: PNAS (2014)
Institution: Lund University
Research Areas: Cancer research
Cell Lines: PC-3 (Human prostate cancer cells)
Summary: This study showed that the clinically relevant lipid kinase phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) plays an important role in cancer cell invasion and survival by regulating the PI3K/AKT/androgen receptor pathways. Elevated levels of PIP5K1α contribute to cancer cell proliferation, survival, and invasion. In this context, the authors introduce a newly developed compound, ISA-2011B, with promising anticancer effects by inhibiting the PIP5K1α-associated AKT pathways. The authors propose that PIP5K1α may be used as a potential therapeutic target for the treatment of advanced prostate cancer. The Holomonitor M3 imaging system was applied to capture living PC-3 cells in culture during treatment.