Customer Publication

The Role of Pi3k/akt-related Pip5k1α and the Discovery of Its Selective Inhibitor for Treatment of Advanced Prostate Cancer

Authors: J. Semenas et al.

Journal: PNAS (2014)

Institution: Lund University

Research Areas: Cancer research

Cell Lines: PC-3 (Human prostate cancer cells)

Summary: This study showed that the clinically relevant lipid kinase phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) plays an important role in cancer cell invasion and survival by regulating the PI3K/AKT/androgen receptor pathways. Elevated levels of PIP5K1α contribute to cancer cell proliferation, survival, and invasion. In this context, the authors introduce a newly developed compound, ISA-2011B, with promising anticancer effects by inhibiting the PIP5K1α-associated AKT pathways. The authors propose that PIP5K1α may be used as a potential therapeutic target for the treatment of advanced prostate cancer. The Holomonitor M3 imaging system was applied to capture living PC-3 cells in culture during treatment.

Keywords: holomonitor M3, cell Morphology, cancer metastasis, drug discovery, kinase inhibitor, targeted therapy

Read the article …

Phase Holographic Imaging PHI AB
Skiffervägen 48
224 78 Lund
+46 46 38 60 80

Phase Holographic Imaging PHI Inc.
265 Franklin Street Suite 1702
Boston, MA 02110
+1 617-963-5150


VAT: SE556542781101

Securities Identification

ISIN: SE0005504636
LEI: 549300JZR79QYESM6296

HoloMonitor® is a registered trademark
Copyright © 2012-2021
Phase Holographic Imaging PHI AB

Phase Holographic Image logo in white

PHI Theme 3.12.2