The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma Cells
Nano Letters (2017)
Institution: Tel Aviv University, Israel
Cell Line: MDA231 (Human breast carcinoma cells)
Research Area: Cancer research
Conclusions: Authors demonstrate that vimentin stiffens cells and enhances cell migration in dense cultures, but exerts little or no effect on the migration of sparsely plated cells. These results suggest that cell–cell interactions play a key role in regulating cell migration, and coordinating cell movement in dense cultures. Their findings pave the way toward understanding the relationship between cell migration and mechanics in a biologically relevant context.