Customer Publication

The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma Cells

Authors: Yonatan Messica, Adi Laser-Azogui, Tova Volberg, Yair Elisha, Kseniia Lysakovskaia, Roland Eils, Evgeny Gladilin, Benjamin Geiger, Roy Beck

Journal: Nano Letters (2017)

Institution: Tel Aviv University

Research Areas: Cancer research

Cell Lines: MDA231 (Human breast carcinoma cells)

Summary: Authors demonstrate that vimentin stiffens cells and enhances cell migration in dense cultures, but exerts little or no effect on the migration of sparsely plated cells. These results suggest that cell–cell interactions play a key role in regulating cell migration, and coordinating cell movement in dense cultures. Their findings pave the way toward understanding the relationship between cell migration and mechanics in a biologically relevant context.

Keywords: HoloMonitor M4, Cell motility, Cell mechanics, Biophysics, Vimentin, Collective motility, Metastasis

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