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The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma Cells
Journal: Nano Letters (2017)
Institution: Tel Aviv University
Research Areas: Cancer research
Cell Lines: MDA231 (Human breast carcinoma cells)
Summary: Authors demonstrate that vimentin stiffens cells and enhances cell migration in dense cultures, but exerts little or no effect on the migration of sparsely plated cells. These results suggest that cell–cell interactions play a key role in regulating cell migration, and coordinating cell movement in dense cultures. Their findings pave the way toward understanding the relationship between cell migration and mechanics in a biologically relevant context.