The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma Cells

Y. Messica et al.

Nano Letters (2017)

Institution: Tel Aviv University, Israel

Cell Line: MDA231 (Human breast carcinoma cells)

Research Area: Cancer research

Tags: HoloMonitor M4, Cell motility, Cell mechanics, Biophysics, Vimentin, Collective motility, Metastasis

Conclusions: Authors demonstrate that vimentin stiffens cells and enhances cell migration in dense cultures, but exerts little or no effect on the migration of sparsely plated cells. These results suggest that cell–cell interactions play a key role in regulating cell migration, and coordinating cell movement in dense cultures. Their findings pave the way toward understanding the relationship between cell migration and mechanics in a biologically relevant context.

Read the article …