Customer Publication

Therapy-Induced Senescent/Polyploid Cancer Cells Undergo Atypical Divisions Associated with Altered Expression of Meiosis, Spermatogenesis and EMT Genes

Authors: Joanna Czarnecka-Herok et al.

Journal: International Journal of Molecular Sciences (2022)

Institution: Polish Academy of Sciences

Research Areas: Cancer research

Cell Lines: HCT116, MCF-7 (Human colon cancer, Breast cancer cells)

Summary: Upon anticancer treatment, cancer cells can undergo cellular senescence, i.e., the temporal arrest of cell division, accompanied by polyploidization and subsequent amitotic divisions, giving rise to mitotically dividing progeny. In this study, the authors documented that escape from senescence/polyploidy of cancer cells is connected with the presence of small descendants inside the giant cells and the transcriptome gradual adaptation related to meiosis and spermatogenesis. With HoloMonitor M4, authors can see the small cells are released from giant mother cells. The giant cells are multinucleated, and some of the subnuclei may possess a proper set of chromosomes, which allows them to survive.

Keywords: sbem scans, cancer, cell senescence, chemotherapy, polyploidization, soma-to-germline transition, senescence escape

Read the article …

Phase Holographic Imaging PHI AB
Skiffervägen 48
224 78 Lund
Sweden
+46 46 38 60 80
info@phiab.se

Phase Holographic Imaging PHI Inc.
265 Franklin Street Suite 1702
Boston, MA 02110
USA
+1 617-963-5150
info@phiab.com

Invoicing

VAT: SE556542781101
faktura@phiab.se

Securities Identification

ISIN: SE0005504636
LEI: 549300JZR79QYESM6296

HoloMonitor® is a registered trademark
Copyright © 2012-2021
Phase Holographic Imaging PHI AB

Phase Holographic Image logo in white

PHI Theme 3.12.2