Transcription Regulation of Chemokine Receptor CXCR4 by Nuclear Respiratory Factor 1 (NRF1) Controls Estrogen-Induced Malignant Transformation of Breast Epithelial Cells to Breast Cancer Stem Cells
AACR Annual Meeting (2016)
Conclusions: Chemokine receptor CXCR4 is involved in the maintenance of the stemness property of stem cells, aging, and metastasis of cancer. NRF1 is one of the major transcription factors that control the transcription of CXCR4. In this study, the authors have investigated whether transcription regulation of CXCR4 by NRF1 controls the estrogen-induced malignant transformation of breast epithelial cells to breast cancer stem cells.