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Ulleungdin, a lasso peptide with cancer cell migration inhibitory activity discovered by the genome mining approach

Authors: Sangkeun Son, Mina Jang, Byeongsan Lee, Young-Soo Hong, Sung-Kyun Ko, Jae-Hyuk Jang, Jong Seog Ahn

Journal: J. Nat. Prod. (2018)

Institution: Korea University of Science and Technology (UST)

Research Areas: Cancer Research

Cell Lines: A549 (Human lung carcinoma)

Summary: Ulleungdin, a new lasso peptide was isolated from Streptomyces KCB13F003. Structural analysis of ulleungdin, as well as cancer cell invasion and migration, were studied. Ulleungdin affects invasivity as measured by a transwell assay, while there was a low and not increasing cytotoxicity. Using HoloMonitor is was shown that Ulleungdin inhibited motility and migration of human lung carcinoma A549 cells. Increasing concentrations of Ulleungdin increasingly affected cell motility.

Keywords: HoloMonitor M4, Cell motility, Cell migration

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