Scientists at UCSF-PHI Center of Excellence map the genetic progression of invasive skin cancer

Utilizing precision genetic engineering and PHI’s HoloMonitor technology, scientists at University of California, San Francisco, have for the first time been able to monitor and map how mutations break down the genetic protection against skin cancer, allowing harmless moles to transform into invasive skin cancer. The new research, which promises to improve skin cancer treatment by allowing malignant forms to be identified earlier, was recently published in two companion papers in the prestigious and high impact scientific journal Cancer Cell.

“It is our role and vision to provide medical scientists with the new scientific tools they need to achieve significant advancements. The discoveries made by the scientists at UCSF are a perfect example of this”, said Peter Egelberg, CEO and founder of PHI.

REFERENCES

• Evolution of Melanoma Reveals Opportunities for Intervention, UCSF News Center
• Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation, Cancer Cell
• Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution, Cancer Cell