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University of California San Francisco – Holographic Imaging Cytometry Center of Excellence

University of California, San Francisco (UCSF) and PHI have jointly created a regional Holographic Imaging Cytometry Center of Excellence headed by Dr. Robert Judson-Torres. Located at the UCSF Helen Diller Family Comprehensive Cancer Center, the Center’s activities focus on bringing the benefits of holographic cytometry and machine-learning to the UCSF research community, by providing education and technical support.

The recurring UCSF-PHI symposium serve as a forum for scientists who worldwide develop new therapies and diagnostic techniques for melanoma and other cancers.

The speakers at the UCSF-PHI symposium 2018.

Holographic cytometry permits simultaneous quantification of cell division, death, senescence, and motility of adherent cells over long-term culture.

Dr. Robert Judson-Torres

University of California, San Francisco

Dr. Robert Judson-Torres

Principal Investigator and a Sandler Fellow at the UCSF Department of Dermatology

Judson's research interests focus on the networks of genes and environmental factors that stabilize cell states in adult mammalian organisms, and, conversely, the coordinated sets of destabilizing factors which can lead to tumorigenesis. He is also actively involved with exploring new models of scientific training, communication and publication, including experimenting with forums for post-publication peer review, reproducibility initiatives, and strategies for training the scientific workforce.

Peer Reviewed Articles and Book Chapters

  • Evaluation of Holographic Imaging Cytometer HoloMonitor M4 Motility Applications
    Y. Zhang and R. L. Judson
    Cytometry Part A (2018)

    The HoloMonitor software modules for cell tracking and wound healing analysis were evaluated and compared to the more conventional methods transwell migration and transwell invasion. Both HoloMonitor modules were found to be well-correlated with established standards, yielded reproducible results, and at the same time offered distinct advantages. The wound healing assay was the most tractable and automated method with good reproducibility, while the cell tracking module enabled identification of hypermobile subpopulations.

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  • Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
    H. Zeng et al.
    Cancer Cell (2018)

    Utilizing precision genetic engineering and PHI’s HoloMonitor technology, scientists at University of California, San Francisco, have for the first time been able to monitor and map how mutations break down the genetic protection against skin cancer, allowing harmless moles to transform into invasive skin cancer.

    Read more
  • Quantification of mammalian tumor cell state plasticity with digital holographic cytometry
    M Hejna, A Jorapur, Y Zhang, J S Song and R L Judson
    SPIE Conference Proceedings (2018)

    Working with a HoloMonitor M4 digital holographic cytometry platform, we have established a machine learning-based pipeline for high accuracy and label-free classification of adherent cells.

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  • Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
    I. Yeh et al.
    Nature Communications (2017)

    HoloMonitor was used to measure cell volume. Together with other methods the results identify DPN (deep penetrating nevus) as an intermediate melanocytic neoplasm, with a progression stage positioned between benign nevus and DPN-like melanoma.

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  • High accuracy label-free classification of single-cell kinetic states from holographic cytometry of human melanoma cells
    M. Hejna et al.
    Scientific Reports (2017)

    The authors used machine learning to develop a method for robust and kinetic label-free classification of single adherent cells info functional states.

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Interviews and News

Single Cell Tracking for early Skin Cancer Detection

Melanoma, the most dangerous form of skin cancer, is increasing. In the US, melanoma is one of the most common cancers among young adults. However, if the disease is caught early, then it can be cured. A research team, led by Dr Robert Judson-Torres, is tracking single cells when studying melanoma at an early stage.
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New Publication shows Advantages of using HoloMonitor® for Cell Movement Assessment

Understanding of cell movements is essential in many aspects of cell biology research, and crucial not least in cancer research.
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BRAF Mutation

New CEO commentary: “Understanding Skin Cancer”

PHI’s CEO and founder Peter Egelberg comments the latest research results by the scientists at the PHI/UCSF Holographic Imaging Cytometry Center of Excellence.
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Scientists at UCSF-PHI Center of Excellence map the genetic progression of invasive skin cancer

Utilizing precision genetic engineering and PHI’s HoloMonitor technology, scientists at University of California, San Francisco, have for the first time been able to monitor and map how mutations break down the genetic protection against skin cancer.
Read More

University of California, San Francisco and Phase Holographic Imaging establish Center of Excellence

University of California, San Francisco (UCSF) and Phase Holographic Imaging (PHI) have agreed to expand their on-going collaboration and establish a regional Holographic Imaging Cytometry Center of Excellence, located at the UCSF Helen Diller Family Comprehensive Cancer Center.
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PHI provides second HoloMonitor® to University of California, San Francisco to accelerate skin cancer research

PHI has entered into a collaboration agreement with University of California, San Francisco (UCSF) to accelerate ongoing skin cancer research at UCSF. Under the 11 month agreement, PHI will provide a HoloMonitor® M4.5 with a motorized stage to supplement the instrument which UCSF purchased previously for preclinical research in the field. “A key strategic goal for …
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Featured Application

Holographic Imaging Cytometer HoloMonitor M4 Motility Applications

UCSF Helen Diller Building

Location

Helen Diller Family Comprehensive Cancer Center
1450 3rd St, San Francisco
CA 94158, USA

Other Partnerships

Northeastern University

The joint program of excellence between Northeastern University and PHI began in late 2014. Since then HoloMonitor technology has rapidly established itself as a technology of choice for label-free kinetic cellular analysis.
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Malmö University

PHI and Malmö University have a long-standing collaboration, dating back to 2008. The collaboration has resulted in several peer reviewed publications and a doctoral thesis.
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