Archives: Commentaries


The Label-free Promise

To transform an invention to a product that can be purchased by any scientist is the often unappreciated but crucial role of commercializing enterprises. This was the underlying theme of my presentation at SPIE 2018, “The evolution of Phase Holographic Imaging from a research idea to publicly traded company”.

Life is a mess

In our daily lives, we all know how important it is to plan ahead to avoid a future mess. Ironically, we ourselves are such a future mess.

Fighting cancer with nanoparticles

Using HoloMonitor, scientists at Northeastern University have shown that paclitaxel-resistant ovarian cancer cells stopped multiplying by cell division when treated with nanoparticles. Ovarian cancer causes more deaths than any other cancer of the female reproductive system.

No Blood, No Tumor

Scientists at Boston Children’s Hospital have used HoloMonitor to study living bone cancer cells. By studying their dynamics, they have successfully for the first time distinguished aggressive bone cancer cells that promote blood vessel formation from the harmless counterparts that do not promote blood vessel formation.

Big Data, Fewer Cells

Scientists at Holographic Imaging Cytometry Program of Excellence at Northeastern University have developed a method to compare time series data of drug treated cells with untreated cells.

3D Culture

Using HoloMonitor and a public domain image processing software called Image J, the researchers from Northeastern University have developed a method for cell experiments based on cells cultured in a 3-dimensional collagen gel. They show that this new method is clearly superior to conventional methods, based on cells cultured on a 2-dimensional.

Big Pharma, Big Data

Imaged-based time-lapse cytometers, as our HoloMonitor, creates huge amounts of information on how cells interact and multiply over long time periods. Combined with Big Data technology, such novel instrumentation will provide cell biologists and the pharmaceutical industry with a game changing new tool to better understand complex cellular interactions and through this hopefully cure cancer.

Label-free High Content Screening

The current form of high-content screening is based on conventional microscopy. The core technology of HoloMonitor, holographic time-lapse microscopy, creates 3D-movies of unstained living cells that can be computer-processed without requiring the use of toxic labels. This new ability opens the door to more realistic high-content screening of living cells and their behavior over time.


The progress by Northeastern University and other customers have shown that HoloMonitor technology has the potential to be the non-destructive tool that makes large scale immunotherapies successful and affordable to all patients.
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AACR 2015

Our participation at the AACR 2015 was further strengthened by three presentations by scientists associated with the Center of Excellence for holographic imaging at Northeastern University in Boston, USA.